Denmark - Aarhus Universityhospital

Dr. Claus Simonsen

Dr. Claus Simonsen
”I enjoy being part of this project where doctors collaborate across borders to help stroke patients we otherwise could not treat.”

In Danish: “Jeg er glad for at vćre en del at dette projekt, hvor lćger samarbejder over landegrćnser for at hjćlpe stroke patienter, som vi ikke tidligere har kunnet behandle.”

France - Hospices Civils de Lyon

Prof. Norbert Nighoghossian

Prof. Norbert Nighoghossian
“The WAKE-UP trial is a critical challenge for testing the eligibility of T-pa based on MRI for patients waking up with a stroke.”

In French: “L'essai WAKE-UP: un enjeu majeur pour l'éligibilité IRM des accidents du réveil au T-pa.“

Spain - Hospital Dr. Josep Trueta Girona

Prof. Salvador Pedraza

Prof. Salvador Pedraza
“The WAKEUP project is a revolution in the treatment of patients with stroke based in the use of imaging biomarkers from Magnetic resonance.”

In Spanish: “El Proyecto wake-up es un revolución en el tratamiento de los pacientes con ictus basada en la aplicación de biomarcadores de imagen por resonancia magnética.”

Germany - Charité Berlin

PD Dr. Martin Ebinger

PD Dr. Martin Ebinger
“The WAKE-UP trial is a unique opportunity to prove the efficacy of MRI-based thrombolysis in patients with unknown symptom onset. Results of this trial will change clinical practice and influence the design of future trials regarding thrombectomy.”

In German: “Die WAKE-UP Studie ist eine einzigartige Möglichkeit die Wirksamkeit der MRT-basierten Thrombolyse bei Patienten mit unbekanntem Zeitfenster nachzuweisen. Die Ergebnisse dieser Studie werden die klinische Praxis verändern und das Design zukünftiger Studien, z.B. im Zusammenhang mit der mechanischen Rekanalisation beeinflussen.“

United Kingdom - University of Glasgow

Prof. Keith Muir

Prof. Keith Muir
“Intravenous thrombolysis greatly improves the chances of recovery after stroke, and we need to extend its use to all those who might benefit from treatment. WAKE-UP is a key trial that will establish whether use can be expanded to the large group of patients in whom onset time cannot be determined.”

Belgium - KU Leuven

Prof. Robin Lemmens

Prof. Robin Lemmens
„As neurologists we all feel powerless when patients present with a stroke after waking up since the treatment options we have in acute stroke cannot be initiated. The WAKE-UP trial will hopefully result in therapeutic strategy for these patients in whom stroke onset time is unknown.”

In Dutch: „Als neurologen voelen we ons vaak machteloos wanneer patiënten zich op de spoedgevallen aanmelden met een beroerte die ontdekt werd na het ontwaken, omdat er geen behandelingsopties zijn. De WAKE-UP studie zal hopelijk leiden tot een therapeutische strategie voor deze patiënten bij wie een het begin tijdstip van de beroerte onbekend is.“

In French: “Etant neurologues on se sent souvent impuissants face ŕ des patients ayant un accident vasculaire cérébral la nuit mais constaté au réveil, vu qu’actuellement nous ne disposons pas d’une stratégie de traitement. Nous espérons que l’étude "WAKE-UP" nous procurera les éléments nécessaires pour améliorer le traitement de ces patients dont l’heure de l’accident cérébral vasculaire est inconnue.”